FAQs for Healthcare Professionals

A: Yes, NITYR contains the active ingredient nitisinone. NTBC is an abbreviation for nitisinone and the two terms mean the same thing.

A: NITYR tablets are tasteless.

A: Cycle™ Pharmaceuticals manufactures NITYR (nitisinone) tablets in Switzerland.

A: NITYR is stable² at room temperature between 68° and 77°F (20° and 25°C), allowing for excursions between 59° and 86°F (15° and 30°C) until its expiry date, and so freeing your patients from having to refrigerate the medication. It has a shelf life of 36 months (3 years). NITYR tablets are tasteless, small (baby aspirin sized), easy to swallow and can be taken with or without food at any time of the day.

For younger patients or patients that can’t swallow tablets, NITYR can also be converted to an oral suspension (see video and supporting materials here) or can be crushed and mixed with applesauce. See full instructions for use here.

A: Yes, clinical trials have demonstrated NITYR is bioequivalent¹ to Orfadin, which means that it has the same efficacy, safety and side effects, and may offer patients and their families greater convenience. Further information is available here.

A: NITYR tablets were designed to be more convenient for your patients because they can be stored at room temperature between 68° and 77°F (20° to 25°C), allowing for excursions between 59° and 86°F (15° and 30°C), with less likelihood of the formation of potentially toxic impurities².

Even in accelerated conditions (40°C; 104°F and 75% RH) and over 6 months, NITYR does not surpass the impurity limits established by the FDA. See graph here for more details.

A: NITYR may offer patients greater convenience. NITYR tablets are tasteless, very small³ (baby aspirin sized), do not require refrigeration² and can be taken with or without food.

NITYR also offers a Free Trial Offer⁴ and a Diet and Low Protein Food Program⁵ for eligible patients.

A: It’s easy to prescribe NITYR to your patients with HT-1. More information and a downloadable enrollment form can be found here. If the patient is not sure, they can also try NITYR for free. Click here to learn more.

A: NITYR is a new option for the treatment of HT-1 and may offer both convenience for patients and a price advantage. NITYR tablets are tasteless, very small, do not require refrigeration and can be taken with or without food. The Diet and Low Protein Food Program⁵ may offer benefits and enable access to wider range of medical foods and formulas.

A: NITYR tablets are very small³ (baby aspirin sized) and can be swallowed by patients from 3 years old. However, the ability of the patient to swallow the tablet should be established (a Free Trial Offer⁴ is available).

For those unable to swallow a tablet, NITYR can be converted to a suspension that can be administered via an oral syringe and stored for up to 24 hours at room temperature before use. If your patient can swallow soft food, NITYR tablets can also be crushed and added to applesauce. Further information and a short video are available here.

A: Yes, the NITYR Patient Support Program is available to patients. The patient support team is available so your patients can gain advice and support with access to a pharmacist when they need help or have any questions. Home delivery and proactive refills are also provided, making this process more convenient for your patients as well. We also offer $0 co-pay for eligible patients⁶.

For more information please refer patients to www.nityr.us or call 1-800-847-8714.

A: As part of Cycle’s dedication to providing NITYR to patients in an accessible and affordable manner, we provide a $0 co-pay⁵ to eligible commercially insured patients (up to $15,000 per patient annually). For more information, please contact our NITYR Patient Support Team on 1-800-847-8714

A: Cycle Pharmaceuticals has partnered with Cambrooke Therapeutics^TM to support patients taking NITYR with the protein formulas and low protein foods they rely on. Patients will receive a $200 monthly contribution⁵ for two years to spend on Cambrooke Therapeutics’ medical foods and formulas. Find out more here. For questions on this Program, call the Cambrooke team on 1-866-456-9776

A: The NITYR Patient Support Team can complete a full benefits investigation for your patients. Please complete the enrollment form and send it back to the support team. You and your patients will be informed of the results from the investigation to support your decision making. Patients undergoing the NITYR Three-Week Free Trial Offer⁴ will also receive the information on their benefits investigation. Enrollment forms can be faxed to 1-800-842-5163.

A: There is a NITYR Three-Week Free Trial Offer⁴, that will give your patients an opportunity to decide if NITYR is right for them.

During the three-week trial, your patient will receive three calls from our NITYR Patient Support Team including an initial call to discuss NITYR and how to administer the medication. If you or your patients have any questions before, during or after the trial, our Patient Support Team is available on 1-800-847-8714.

More information on the Free Trial can be found here.

A: Please contact the NITYR Patient Support Team on 1-800-847-8714, or contact our Medical Information team on 1-855-831-5413.

A: For appointments and patient materials in the US, please contact 1-800-903-1793. For information about NITYR availability in other countries outside of the US, please contact hello@nityr.us