* Patients can try NITYR for three weeks for free as long as their doctor prescribes it. Subject to terms and conditions, eligibility criteria, and to other federal and state law.

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* For eligible commercially insured patients. Doctor’s prescription required. Subject to terms and conditions and eligibility criteria. Program not available for government-insured patients and subject to other federal and state law.

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Safety InformationPrescribing Information

Why Choose NITYR for Your Patients?

NITYR (nitisinone) tablets are a new option for treatment of hereditary tyrosinemia (HT-1).

Your patients living with HT-1 may be unaware of this new option for nitisinone (NTBC) – the first in many years – or may have a number of questions regarding the difference compared to the current nitisinone on the market.

NITYR tablets:

  • Are bioequivalent to Orfadin*1
  • The tablet for all life stages
  • Are very small2 (baby asprin sized) and tasteless
  • Can be stored at room temperature, do not require refrigeration and have a shelf life of 36 months (3 years)3
  • Can be taken with or without food
  • Have a Food Program4 and a Free Trial5 available
  • Have a price advantage compared to traditional nitisinone
  • Come with a $0 co-pay for eligible commercially insured patients6

Bioequivalence

NITYR is bioequivalent to Orfadin, which means that it has the same efficacy, safety and side effects, and may offer patients and their families greater convenience – see graph below.

Graph demonstrating Orfadin 10 mg arithmetic mean compared to NITYR 10 mg arithmetic mean, showing bioequivalence

Improved stability

NITYR tablets were designed to be more convenient for your patients because they can be stored at room temperature between 68° and 77°F (20° to 25°C), allowing for excursions between 59° and 86°F (15° and 30°C), with less likelihood of the formation of potentially toxic impurities.

As demonstrated in the graph below, even in accelerated conditions (40°C; 104°F and 75% RH) and over 6 months, NITYR does not surpass the impurity limits established by the FDA.

NITYR does not require refrigeration. They have a shelf life of 36 months (3 years). NITYR tablets are also very small (baby aspirin sized), can be taken with or without food and may have a price advantage compared to the traditional nitisinone on the market (including a $0 co-pay for eligible commercially insured patients).

Drug product stability – accelerated conditions 40°C, 75% RH

1 Data on file NIT/02/17 2 Data on file NIT/03/18 3 Data on file NIT/01/17 4 Diet and Low Protein Food Program: Subject to terms and conditions and eligibility criteria. This program is for eligible commercially insured patients only. Not available for government-insured patients and subject to other federal and state law. 5 Free trial offer: Subject to terms and conditions and eligibility criteria. Patients can try NITYR for three weeks for free as long as their doctor prescribes it. Subject to terms and conditions, eligibility criteria, and to other federal and state law. 6 $0 co-pay for eligible commercially insured patients (up to $15,000 per year per patient).

*Orfadin is a registered trademark licensed by Sobi, Inc. or its affiliates.

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