* Patient can try NITYR for 30 days, one-time, for free, as long as their doctor prescribes it and that have never used NITYR before. Subject to terms and conditions, eligibility criteria, and other federal and state law.

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* For eligible commercially insured patients. Doctor’s prescription required. Subject to terms and conditions and eligibility criteria. Program not available for government-insured patients and subject to other federal and state law.

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Safety InformationPrescribing Information

Administering NITYR to infants

NITYR Tablets are tasteless and come in very small¹ and convenient 2 mg, 5 mg, and 10 mg tablets. These tablets can be converted to a suspension for administration to a younger child unable to swallow tablets via oral syringe2, or they can be crushed and added to applesauce. The suspension can be stored at room temperature for 24 hours before use. The following instructions will help your patients learn the process of administering NITYR Tablets to their child:

Administration using an oral syringe

Greater convenience in mind

Preparing a suspension of NITYR requires less than 1 minute of active preparation and administration time, and can be prepared on the go. This diagram will help you explain the process to your patients.

Administration using Applesauce

  1. Crush one NITYR Tablet using two spoons (a tablet crusher is available from the NITYR Patient Liaison Services for free).

  2. Add all the crushed tablet powder to one full teaspoon of applesauce in a clean glass or bowl.

  3. If giving more than one tablet, repeat the process above, adding the powder to the same applesauce.

  4. Mix well in a bowl or glass.

  5. Feed the mixture to the child using a teaspoon.

  6. To make sure you give the child all the medicine, add another full teaspoon of applesauce to the same glass or bowl and stir. Again, feed the mixture to the child.

  7. Use the NITYR-applesauce mixture within 2 hours of preparation.

For more information on administering NITYR using an oral syringe, or with applesauce see the full instructions for use or or refer to the prescribing information.

30-Day Free NITYR Program3

If you or your patients believe that NITYR may offer greater convenience then they can try NITYR for free. The 30-Day Free NITYR Program will help your patients decide if NITYR is right for them.

NITYR is bioequivalent4 to Orfadin*capsules which means that it has the same efficacy, safety and side effects as your patient's current nitisinone. During the 30-Day Free Program your patients will still receive their Orfadin medication as usual, and because NITYR is bioequivalent to Orfadin, patients can move back to Orfadin at any time during the Free Program if they wish.

1 Data on file: NIT/03/18 2 Data on file: NIT/01/19 3Free NITYR Program: Patients can try NITYR for 30 days, one time, for free, as long as their doctor prescribes it. Subject to terms and conditions, eligibility criteria, and other federal and state law. Terms and Conditions and eligibility criteria are available at www.nityr.us/offertcs.4Data on file: NIT/02/20 *Orfadin is a registered trademark licensed by Sobi, Inc. or its affiliates.


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