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Safety InformationPrescribing Information

NITYR Diet and Low Protein Food Program1

What I really like about the NITYR program is the $200 monthly contribution to Cambrooke Therapeutics food," Carrie explains. "It allows us flexibility to order medical foods for our child, who cannot eat a high-protein diet. There are very few foods on the market that are available to kids with tyrosinemia, and this allows him to have access to pasta, rice, ravioli, pizza – all low protein – and it saves our family a lot of financial burden.

Carrie - Mother of Ethan, 5 yr old NITYR patient

NITYR (nitisinone) tablets -Food Program

  • Support that makes a real difference

    At Cycle Pharmaceuticals, we appreciate that living with HT-1 is not only a matter of treatment, but it involves other daily challenges such as diet management and its related expenses.
     
    For this reason, we have partnered with Cambrooke TherapeuticsTM, a global leader in therapeutic medical nutrition, to support our patients in the purchasing of protein formulas and low protein foods. If you decide NITYR is right for you, you will receive $200 monthly contribution towards therapeutic medical nutrition for you or your child for 2 years.

    For more details about this Program please contact Cambrooke Therapeutics on 866-456-9776, opt. 2.

    If you are still considering if NITYR is right for you, then the NITYR Three-Week Free Trial Offer2 may also be of interest.

  • Redeeming your $200 monthly contribution

    Redeeming your monthly contribution is an easy process, simply:

    1. Take a picture of the packing slip that comes with your NITYR medication, making sure that the text is in focus and can be easily read, and send the photo to info@cambrooke.com
    2. Go to Cambrooke Therapeutics and choose the products you would like to spend your $200 montly contribution on, from delicious metabolic food formulas containing Tylactin™ with GMP, to low protein pasta, pizza and snacks.
    3. Call the Cambrooke Therapeutics Customer Service Team on 866-456-9776 and select option 2 to place your order.
  • Experience NITYR

    If you are still considering if NITYR is right for you and your family, click here to find out more about our NITYR Three-Week Free Trial Offer.

    If you are considering NITYR, speak to your HCP, your dietitian or your clinic today – you don’t need to wait until your next appointment. To help you get the most out of the discussion, we’ve gathered some common questions to ask your HCP. Simply follow the link to download the guide here.
     

1Diet and Low Protein Food Program: Subject to terms and conditions and eligibility criteria. This program is for eligible commercially insured patients only. Not available for government-insured patients and subject to other federal and state law. 2Free Trial Offer: Subject to terms and conditions and eligibility criteria. Eligible patients can try NITYR (nitisinone) tablets for 21 days for free as long as their doctor prescribes it. Subject to other federal and state law. Cambrooke Therapeutics is a registered trademark of Cambrooke Therapeutics, Inc.

This website is for education purposes only. It is not intended to be, and should not be used as, a substitute for medical advice.

Important safety information

Do not take NITYR if you are allergic to nitisinone or any other ingredients. Tell your healthcare professional about any health problems, and if you are pregnant or planning to become pregnant, before starting treatment.
The warnings and precautions that come with NITYR include:

Increased levels of plasma tyrosine, eye symptoms, developmental delay and skin changes

  • Inadequate restriction of tyrosine and phenylalanine intake can result in elevations of plasma tyrosine
  • At plasma tyrosine levels above 500 micromol/L, symptoms can occur including intellectual disability and developmental delay or painful hyperkeratotic plaques (thickening of the skin) on the soles and palms
  • Do not adjust the dosage of NITYR in order to lower the levels of tyrosine in the blood

Changes in blood profile

  • Patients can develop leukopenia (reduction in the number of white blood cells, which form part of the immune system) and severe thrombocytopenia (abnormally low levels of platelets, which help the blood clot)
  • Your healthcare professional will monitor platelet and white blood cell counts, and will adjust your medication accordingly
    If you have a question about your dosage, or if you experience any of the symptoms explained above, please speak to your healthcare professional.

Adverse Reactions

The most common adverse reactions (>1%) are elevated tyrosine levels, thrombocytopenia, leukopenia, conjunctivitis, corneal opacity, keratitis, photophobia, eye pain, blepharitis, cataracts, granulocytopenia, epistaxis, pruritus, exfoliative dermatitis, dry skin, maculopapular rash and alopecia.

To report suspected adverse reactions, contact Cycle Pharmaceuticals at 1-855-831-5413 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Patients should keep NITYR and all medicines out of reach of children.

For more detailed information, please refer to the full prescribing information, which can be found at www.nityr.us/pi

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